Corresponding decrease in neuronal markers signals progressive parvalbumin neuron loss in MAM schizophrenia model
نویسندگان
چکیده
منابع مشابه
Corresponding decrease in neuronal markers signals progressive parvalbumin neuron loss in MAM schizophrenia model.
Alteration in normal hippocampal (HPC) function attributed to reduced parvalbumin (PV) expression has been consistently reported in schizophrenia patients and in animal models of schizophrenia. However, it is unclear whether there is an overall loss of interneurons as opposed to a reduction in activity-dependent PV content. Co-expression of PV and the constitutively expressed substance P (SP)-r...
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BACKGROUND Loss of parvalbumin interneurons in the hippocampus is a robust finding in schizophrenia brains. Rats exposed during embryonic day 17 to methylazoxymethanol acetate exhibit characteristics consistent with an animal model of schizophrenia, including decreased parvalbumin interneurons in the ventral hippocampus. We reported previously that peripubertal administration of diazepam preven...
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ژورنال
عنوان ژورنال: The International Journal of Neuropsychopharmacology
سال: 2014
ISSN: 1461-1457,1469-5111
DOI: 10.1017/s146114571400056x